Pressure variation tendency and countermeasures in gas sterilization process of high-level biosafety laboratory airtight devices

 In order to study the pressure variation tendency of airtight devices during sterilization process in the high-level biosafety laboratory, taking a main pipe exhaust high efficiency particulate air filter unit in ABSL-3 as a research object, selects two types of disinfection equipment and sets four kinds of sterilization procedure to real-timely monitor the pressure and temperature changes of the high efficiency particulate air filter unit during sterilization process and qualitatively analyse the cause of pressure variations. The results show that a large positive pressure difference will occur in the high efficiency particulate air filter unit when the pressure is not controlled during the sterilization process, whereas, the pressure difference is relatively stable when the pressure is controlled. Proposes a pressure control strategy for the sterilization of airtight devices to control biosafety risks.